Comment submitted by Silvio Mazzella Jr.
AnonymousOtherIndividual
Summary: Silvio Mazzella Jr. provides a series of scientific observations and research citations regarding the potential neurotoxic, endocrine-disrupting, and ecotoxicological effects of specific pesticides like fenpropathrin, famoxadone, and cymoxanil. The commenter expresses concerns about human health impacts (particularly on children) and environmental risks without explicitly requesting a specific regulatory change to the proposed action.
Document ID EPA-HQ-OPP-2026-0529-0001
Opinion. As part of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),
I consider it reasonable for people
within 2000 meters of crop sprays
be informed about the detox
of the various crop chemicals.
[ Hint. Autism and SIMONE plus, by S( Conte )M Jr. ].
Comment EPA-HQ-OA-2025-0261-0006
Posted by U.S. EPA on August 15, 2025.
[ https://www.regulations.gov/comment/EPA-HQ-OA-2025-0261-0006 ].
Opinion.
Special attention should be given within 2000 meters
of elementary schools, because of utmost caution,
to avoid subacute impact on young kidneys,
and/or possible endocrine-disrupting effects,
by insecticides and fungicides.
Let's take, for example, insecticide fenpropathrin ( FEN )
of PP 5F9177 ( EPA-HQ-OPP-2025-3824 );
"food/feed handling establishments".
Polish researchers of [ PMID : 32385770 ]
used 11.9 mg/kg
to measure female mice Creatinine ( Cr ), plus the proinflammatory cytokines
of TNFα ( TNF-alpha ), and IL-1β ( IL-1beta );
consider IF the labs had approximately increased
minimally for Cr and TNF-alpha ( 0.025 mg/dl +/_ and 0.164 pg/ml +/- , respectfully )
but significantly for IL-1beta
( controls 4.67 +/- 1.154 pg/ml, versus FEN 27.983 +/- 26.382 pg/ml ( p< 0.05 ) ).
The effect of subacute poisoning with fenpropathrin
on mice kidney function and the level
of interleukin 1β and tumor necrosis factor α. ...
[ https://pubmed.ncbi.nlm.nih.gov/32385770/ ].
AND
PubMed "interleukin 1β"
[ https://pubmed.ncbi.nlm.nih.gov/?term=interleukin+1%CE%B2 ].
FENPROPATHRIN
First draft prepared by
P.V. Shah and Douglas McGregor ...
Accessed July 15, 2026
[ https://apps.who.int/pesticide-residues-jmpr-database/Document/55 ].
PP 5F9177 ( EPA-HQ-OPP-2025-3824 ).
I'm concerned about pollinators [ PMID : 33965824; 39591785 ],
and FEN, rather than wide-area mosquito adulticide at the 0.9 ppm ( 90 ppb ) level.
The qPCR analysis of Danio fish brain found
exposure to FEN [ PMID : 31838190 ]
"resulted in a decrease in the messenger (m)RNA expression
of monoamine oxidase (mao), an enzyme that facilitates the deamination of dopamine;
a possible Parkinson disease connection?
By contrast, rat brains at 15mg/kg ( think 15 ppm ) doses for 60 days
had encephalopathy: reduced DOPA and AChE levels,
increased TNF-a, "malondialdehyde, myeloperoxidase, Caspase-3", ...
plus neurodegenerative changes
in the hippocampi ( learning, memory, spatial navigation [ PMID : 23349586 ] ).
Camel milk rescues neurotoxic impairments
induced by fenpropathrin
via regulating oxidative stress, apoptotic,
and inflammatory events in the brain of rats. ...
[ https://pubmed.ncbi.nlm.nih.gov/31838190/ ].
In terms of ecotoxicology,
the Chinese minnow, Gobiocypris rarus,
exposed to FEN 1.5 μg/L ( 0.0015 mg/L ) for 31 days,
had decreased "androgen receptor gene (AR),
estrogen receptor gene (ER1),
and the sex hormone-synthesis-related genes (HMGR, CYP17, and CYP19a)"
[ PMID : 38133404 ];
2.0 μg/L of FEN upregulated juvenile Gobiocypris
"estrogen receptor gene (ER2a),
thyroid hormone receptor gene (TRβ),
and aromatic hydrocarbon receptor genes (AhR1a and AhR2)".
The Developmental Toxicity
and Endocrine-Disrupting Effects
of Fenpropathrin on Gobiocypris rarus
during the Early Life Stage. ...
[ https://pubmed.ncbi.nlm.nih.gov/38133404/ ].
There appears to be Cymoxanil & Famoxadone ( fungicides ) differences by the petitioner,
Interregional Research Project Number 4,
with headquarters at North Carolina State University,
with Brassica ( 15 ppm versus 40 ppm ),
and arugula ( 19 ppm versus 25 ppm ).
Likewise, potatoes have Famoxadone
at 0.02 ppm ( 20 ppb ) with PP 3E9082,
but 0.5 ppm ( 50 ppb ) with PP 3E9081. Why?
Lastly, I'm worried about possible cilantro overlap
caused by Cymoxanil
PP3E9081 ( EPA-HQ-OPP-2024-0156, 19 ppm ),
and
Famoxadone
PP 3E9082 ( EPA-HQ-OPP-2024-0155, 25 ppm ).
Any overlap of these
might have augmented zebrafish side effects,
among them,
zebrafish embryos cardiotoxicity [ PMID : 32961491 ],
and immunotoxicity and neurobehavioral toxicity [ PMID : 31931321 ].
Thank You for considering and discussing my ideas.
Silvio Mazzella Jr. pesticide Fenpropathrin ( TNF-alpha, IL-1beta ). fungicides Famoxadone
and/or Cymoxanil ( cilantro, brassica, arugula, ... ). July 15, 2026
( disclaimer ). IMO.GEM.NTH.SLP. SQP.