Comment from Milind Dixit
AnonymousSupportIndividual
Summary: The commenter provides specific technical feedback and detailed definitions regarding pharmaceutical manufacturing processes, including particle size reduction, blending, granulation, and coating. They specifically request clarifications on the distinction between vibrating and tumbling mills, thermal degradation in hot melt granulation, and residence time calibration in melt extrusion.
I have comments on (a) distinction between a vibrating mill and tumbling mill, (b) Heat transfer and need to consider thermal degradation of the API during hot melt granulation & (c) Need for calibrating the "residence time" of the material during melt extrusion process.