Comment from Non-Nicotine Promotion Organization

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Summary: The Non-Nicotine Promotion Organization (NNPO) expresses significant health concerns regarding the chemical additives and flavorings used in e-cigarettes, particularly their potential toxicity when heated and their risks to children. They argue that these products pose dangers such as DNA damage, microbiome disruption, and risks to pregnant women, thereby supporting stricter oversight or regulation of flavored ENDS.
Dear Sir/Madam of FDA: We hope that the FDA continues to thrive. Generally, e-cigarettes (such as VAPE) and "smoking-related products regardless of nicotine content" are socially understood to be luxury goods, similar to coffee and tea. However, among all luxury goods, those that only have harmful effects on the body are classified as "smoking-related products regardless of nicotine content." This document addresses, from a medical and scientific perspective, concerns about the health hazards posed by ENDS Flavor Solutions for the FDA. We appreciate your understanding of our concerns. Non-Nicotine Promotion Organization (NNPO) Akimasa Fukai as President of NNPO Yuichi Hashimoto, Ph.D. as Medical and Pharmacological Principal Investigator of NNPO 2-5-12, Sotokanda, Chiyoda-ku, Tokyo, Japan. e-mail: y-hashimoto@nnpo.or.jp; Tel: +81-3-5298-6166; Fax: +81-3-5298-6177

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