Comment from Kristiina Vuori

Summary: Dr. Kristiina Vuori, a physician-scientist and professor at the Sanford Burnham Prebys Medical Discovery Institute, supports the draft guidance but recommends explicitly including Optical Genome Mapping (OGM) as an orthogonal method. She argues that OGM provides essential capabilities for detecting large structural variants and chromosomal rearrangements that Next-Generation Sequencing (NGS) may miss.