Comment from Anonymous
AnonymousSupportAcademic
Summary: Allan Peter Davis, representing North Carolina State University, provides toxicogenomic data from the Comparative Toxicogenomics Database (CTD) and AOP-Wiki to support the petition for a pediatric neurodevelopmental warning for acetaminophen. The comment highlights that acetaminophen is a top-ranked chemical association for Autistic Disorder and interacts with multiple biological events in an autism-related adverse outcome pathway.
This PDF provides toxicogenomic support for the petition, showing that acetaminophen is highly ranked in CTD for “Autistic Disorder” and is also identified in a CTD/AOP-Wiki analysis as interacting with most biological events in an autism-related adverse outcome pathway. It is submitted as additional support for a pediatric neurodevelopmental warning for acetaminophen.